Reaction #6698

Reaction equation

7-chlorolepidine

CH3I

diethyl ether

→

7-chloro-1-methyllepidinium iodide

Solvents

CH3CN

Conditions

Workup

1. 1
   Temperatureat reflux for two hours
2. 2
   Otherto give a yellow powder

Procedure

A portion of the 7-chlorolepidine (80 mg) prepared as above was methylated by heating with CH3I (0.5 ml) in CH3CN (1 ml) at reflux for two hours. The mixture was treated with diethyl ether, followed by centrifugation, to give a yellow powder.

Source