Reaction #66937

Reaction equation

164

N-(6-acetylbenzo[d][1,3]-dioxol-5-yl)-3-(benzyloxy)-5-methoxybenzamide

sodium hydroxide

→

2-(3-Benzyloxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one

Solvents

1,4-dioxane

Conditions

Workup

1. 1
   TemperatureThe mixture was refluxed for 24 h
2. 2
   OtherAfter the reaction mixture was evaporated
3. 3
   workup.ADDITION100 mL of 10% ammonium chloride solution was added
4. 4
   Otherthe precipitate was collected
5. 5
   Washwashed with water and acetone

Procedure

Into a suspension of 164 (3.33 g, 0.0079 mmol) in 200 mL of 1,4-dioxane was added sodium hydroxide (2.50 g, 0.0635 mmol). The mixture was refluxed for 24 h. After the reaction mixture was evaporated, 100 mL of 10% ammonium chloride solution was added. The mixture was stirred for 12 h, and then the precipitate was collected and washed with water and acetone.

Source