Reaction #66757

Reaction equation

tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

HCl

Et2O

→

6-(4-Oxospiro[chroman-2,4′-piperidin]-6-yl)nicotinamide dihydrochloride

Solvents

dioxane

dioxane

Conditions

Workup

1. 1
   Otherthe resulted precipitate was collected by aeration
2. 2
   Washwashed with Et2O
3. 3
   Otherto give

Procedure

To a suspension of tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate in dioxane (125 ml) was added 4N HCl in dioxane (125 ml) and the mixture was stirred for 18 h. After Et2O was added to the mixture, the resulted precipitate was collected by aeration, washed with Et2O to give intended compound as a colorless solid.

Source