Reaction #662576

Reaction equation

methylene chloride

Cyclopropylcarboxamidine hydrochloride

10-bromo-3-iodo-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide

hydrazine

→

title compound

Yield 31.0%

10-bromo-3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

Yield 31.0%

Conditions

Workup

1. 1
   Other10-bromo-3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was prepared similarly
2. 2
   OtherThe completed reaction
3. 3
   Filtrationfiltered over celite

Procedure

10-bromo-3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was prepared similarly according to Procedure I. Cyclopropylcarboxamidine hydrochloride was reacted with 10-bromo-3-iodo-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide then hydrazine. The completed reaction was then diluted with methylene chloride and filtered over celite to afford 83 mg (31% yield) of the title compound.

Source