Reaction #66018

Reaction equation

4-fluorodiphenyl ether

chlorosulphonic acid

→

4-(4-fluorophenoxy)benzenesulphonic acid

Solvents

CH2Cl2

Conditions

Workup

1. 1
   OtherThe solvent was evaporated at room temperature
2. 2
   Otherthe residue dried overnight under vacuum

Procedure

To a solution of 4-fluorodiphenyl ether 1b (1.00 g, 5.31 mmol) in dry CH2Cl2 (30 mL) under an argon atmosphere at 0° C., was added chlorosulphonic acid (0.35 mL, 5.31 mmol). The reaction mixture was stirred for 2 h at 0° C. The solvent was evaporated at room temperature and the residue dried overnight under vacuum to give the corresponding 4-(4-fluorophenoxy)benzenesulphonic acid (2b) as a pale-pink hygroscopic solid.

Source