Reaction #66016

Reaction equation

diphenyl ether

chlorosulphonic acid

→

4-phenoxybenzenesulphonic acid

Solvents

CH2Cl2

Conditions

Workup

1. 1
   OtherThe solvent was evaporated at room temperature
2. 2
   Otherthe residue dried overnight under vacuum

Procedure

To a solution of diphenyl ether 1a (2.00 g, 11.8 mmol) in dry CH2Cl2 (30 mL) under an argon atmosphere at 0° C., was added chlorosulphonic acid (0.80 mL, 11.8 mmol). The reaction mixture was stirred for 2 h at 0° C. The solvent was evaporated at room temperature and the residue dried overnight under vacuum to give the corresponding 4-phenoxybenzenesulphonic acid (2a) as pink oil. Compound 2a was used for the next reaction without further work-up.

Source