Reaction #65444

ord-f5a152932e154c3bae7a278924305675

Reaction equation

Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl)methyl]piperazine
O=C(O)C1COc2cc(O)ccc2O1
6-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid
→
O=C(C1COc2cc(O)ccc2O1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
6-HYDROXY-2-{4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN -1-YLCARBONYL}-2,3-DIHYDRO-1,4-BENZODIOXIN
Yield 80.0%

Reactants

Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl)methyl]piperazine
O=C(O)C1COc2cc(O)ccc2O1
6-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThat compound is obtained a yield of 80%

Procedure

That compound is obtained a yield of 80% starting from 1-[bis(4-fluorophenyl)methyl]piperazine and 6-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05420132uspto-grants-1995_05