Reaction #65152

Reaction equation

3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol

potassium hydroxide

→

3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran

Yield 96.2%

Solvents

diethyl ether

Conditions

Workup

1. 1
   Othersynthesized
2. 2
   workup.ADDITIONwas added
3. 3
   OtherThe insoluble material was removed by filtration
4. 4
   Otherthe solvent was removed by distillation under reduced pressure

Procedure

To 1.5 l of diethyl ether was added 12.63 g (33.67 mmol) of 3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol synthesized according to the process of JP-B-2-237985, and 30.2 g of potassium hydroxide was added thereto, followed by stirring at room temperature for 54 hours. The insoluble material was removed by filtration, and the solvent was removed by distillation under reduced pressure to yield 9.5 g (96.2%) of 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran.

Source