Reaction #64903

Reaction equation

Phosphorous oxychloride

sodium hydroxide

5-aminoacenaphthene

sodium nitromalondialdehyde monohydrate

aniline hydrochloride

→

8-Nitro-10-azaacephenanthrene

Solvents

acetic acid

Conditions

Workup

1. 1
   workup.STIRRINGThis mixture was stirred for 10 min
2. 2
   Temperatureheated
3. 3
   Temperatureat reflux for 2 h
4. 4
   Temperatureheating
5. 5
   workup.WAITwas continued for 3 h
6. 6
   TemperatureThe resulting mixture was cooled to room temperature
7. 7
   Extractionextracted with dichloromethane
8. 8
   DryingThe extracts were dried over sodium sulfate and condensed to dryness
9. 9
   OtherThe condensed product was purified
10. 10
    Otherto obtain a fluffy, bright yellow solid, 3.20 g (43%)

Procedure

A mixture of 5-aminoacenaphthene (Grabe, C. Liebigs Ann. der Chemie 1903, 327, 77) (5.0 g, 29.5 mmol) and sodium nitromalondialdehyde monohydrate (Fanta, P. E. Org. Syntheses Coll. vol. 4 1963, 844) (5.51 g, 35 mmol) in acetic acid (140 mL) was stirred for 1 h at room temperature and aniline hydrochloride (5.21 g, 40.2 mmol) was added. This mixture was stirred for 10 min and heated at reflux for 2 h. Phosphorous oxychloride (3 mL, 32.2 mmol) was added and heating was continued for 3 h. The resulting mixture was cooled to room temperature and poured into ice/water (200 mL). The aqueous mixture was neutralized with 2M sodium hydroxide solution and extracted with dichloromethane. The extracts were dried over sodium sulfate and condensed to dryness. The condensed product was purified using flash chromatography (20% hexane/dichloromethane, silica gel) to obtain a fluffy, bright yellow solid, 3.20 g (43%): MS m/e 251 (M+H +); 1H NMR (CD2C12, 300 MHz) δ 3.48-3.55 (m, 4H), 7.56 (s, 1H), 7.68 (d, J=7.0 Hz, 1H), 7.77 (t, J=7.8 Hz, 1H), 8.79 (d, J=8.1 Hz, 1H), 8.94 (d, J=2.5 Hz, 1H), 9.65 (d, J=2.5 Hz, 1H).

Source