Reaction #64861

Reaction equation

3-chloro-2-chloromethyl-1-propene

potassium phthalimide

→

1-PHTHALIMIDO-3-CHLORO-2-METHYLENEPROPANE

Solvents

dimethylformamide

Conditions

Workup

1. 1
   ConcentrationThen the mixture was concentrated in vacuo
2. 2
   Otherafter usual work-up, the product was purified by flash chromatography on silica gel (ethyl acetate:hexane; 15:85) (4.2 g, 78%)

Procedure

A mixture of 3-chloro-2-chloromethyl-1-propene (6.55 g, 50 mmol) and potassium phthalimide (5.6 g, 30 mmol) in anhydrous dimethylformamide (200 ml) was heated two days at 50° C. Then the mixture was concentrated in vacuo and, after usual work-up, the product was purified by flash chromatography on silica gel (ethyl acetate:hexane; 15:85) (4.2 g, 78%).

Source