Reaction #64729

ord-5d1b7b05088e43aab4f8c5301d4e457c

Reaction equation

CCOC(OCC)[PH](=O)OCC
ethyl diethoxymethylphosphinate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
[Cl][Mg][CH2]c1ccccc1
benzylmagnesium chloride
→
CCOC(OCC)[PH](=O)Cc1ccccc1
benzyl(diethoxymethyl)phosphine oxide

Reactants

CCOC(OCC)[PH](=O)OCC
ethyl diethoxymethylphosphinate
—
molar solution
O=C([O-])[O-].[K+].[K+]
potassium carbonate
[Cl][Mg][CH2]c1ccccc1
benzylmagnesium chloride

Reagents

None

Solvents

O
water
CCOCC
diethyl ether

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherto precipitate inorganic salts

Procedure

By a procedure analogous to that of Example 1, but using 1.96 g of ethyl diethoxymethylphosphinate and 20 ml of a molar solution of benzylmagnesium chloride in diethyl ether and adding 4.14 g of potassium carbonate in 5 ml of water to precipitate inorganic salts, benzyl(diethoxymethyl)phosphine oxide is obtained as a colourless oil.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05414133uspto-grants-1995_05