Reaction #64702

Reaction equation

1-ethylpiperidine

formic acid

Meldrum's acid

veratraldehyde

→

3-(3,4-dimethoxyphenyl)propionic acid

Conditions

Workup

1. 1
   Otherreacted at the same temperature for 2 hours

Procedure

After dropwise adding 27.2 g (33.1 ml, 0.24 mol) of 1-ethylpiperidine to 27.6 g (22.6 ml, 0.6 mol) of formic acid under stirring, 7.2 g (0.05 mol) of Meldrum's acid and 8.3 g (0.05 mol) of veratraldehyde were added to the solution which was then heated to 95° C. during 1 hour and reacted at the same temperature for 2 hours. Subsequently the method of Example 1 was followed.

Source