Reaction #64685

Reaction equation

Meldrum's acid

formic acid

hydrochloric acid

veratraldehyde

→

3-(3,4-dimethoxyphenyl)propionic acid

Solvents

triethylamine

Conditions

Workup

1. 1
   Otherprepared
2. 2
   Temperaturemaintained at 90° C. for 2 hours
3. 3
   workup.ADDITIONwere added to the reaction mixture
4. 4
   Otherat 5° C.
5. 5
   Otherfor 16 hours
6. 6
   FiltrationAfter filtration the precipitate
7. 7
   Washwas washed 3 times on the
8. 8
   Filtrationfilter
9. 9
   Otherdried at 40° C. under reduced pressure

Procedure

After weighing 14.4 g (0.1 mol) of Meldrum's acid and 16.6 g (0.1 mol) of veratraldehyde to 50 ml of the mixture of formic acid and triethylamine prepared according to Example 1, the reaction mixture was heated to 90° C. during 1 hour and maintained at 90° C. for 2 hours. After cooling down to room temperature 200 ml of ice-water were added to the reaction mixture, the pH value was adjusted to 1 by adding concentrated hydrochloric acid and the mixture was let stand at 5° C. for 16 hours. After filtration the precipitate was washed 3 times on the filter and dried at 40° C. under reduced pressure.

Source