Reaction #64667

Reaction equation

2-ethoxyphenyl N-(2-ethoxyphenoxysulfonyl)carbamate

2-amino-4,6-dimethoxypyrimidine

→

desired product

Yield 97.5%

1-(2-Ethoxyphenoxysulfonyl)-3-(4,6-dimethoxy-2-pyrimidyl)urea

Yield 97.5%

Solvents

toluene

Conditions

Workup

1. 1
   TemperatureAfter cooling to 30° C.
2. 2
   Filtrationthe precipitate is filtered off
3. 3
   Washwashed with 100 ml of toluene

Procedure

38.1 g of 2-ethoxyphenyl N-(2-ethoxyphenoxysulfonyl)carbamate are dissolved in 500 ml of toluene, 15.5 g of 2-amino-4,6-dimethoxypyrimidine are added at room temperature, and the mixture is heated for 2 hours at 100° C. After cooling to 30° C., the precipitate is filtered off and washed with 100 ml of toluene. 38.8 g of the desired product are obtained with a purity of 98.8%, corresponding to a yield of 96.4% of theory. The melting point for the product is 147°-149° C. 6.5 g of 2-ethoxyphenol are recovered from the mother liquor by distillation.

Source