Reaction #640563

ord-c83f9a78c34a455c8b29550583c48eaa

Reaction equation

Nc1ccccc1B(O)O
2-aminophenylboronic acid
C=CC(=O)Cl
acryloyl chloride
→
C=CC(=O)Nc1ccccc1B(O)O
2-Acrylamido-phenylboronic acid

Reactants

Nc1ccccc1B(O)O
2-aminophenylboronic acid
C=CC(=O)Cl
acryloyl chloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    ExtractionThe product was extracted in acetone
  2. 2
    Otherdried
  3. 3
    Othera rotary evaporator

Procedure

2-Acrylamido-phenylboronic acid (“2-APB”) was synthesized by reacting 2-aminophenylboronic acid with an excess of acryloyl chloride in an aqueous alkaline solution. The product was extracted in acetone and dried using a rotary evaporator. The structure of 2-APB was confirmed using NMR. The purity was shown to be greater than 90%.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08048680B2uspto-grants-2011_11