Reaction #640552

Reaction equation

thionyl chloride

trans-4-pentylcyclohexanecarboxylic acid

pyridine

→

trans-4-pentylcyclohexanecarboxylic acid chloride

Solvents

toluene

Conditions

Workup

1. 1
   Temperatureunder heating to 80° C. or less for 1 hour
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Procedure

20 mL of thionyl chloride was added dropwise to a mixture containing 20.0 g (0.1 mol) of trans-4-pentylcyclohexanecarboxylic acid represented by the following formula (b-i), 0.5 mL of pyridine and 300 mL of toluene in a nitrogen atmosphere, and the mixture was stirred under heating to 80° C. or less for 1 hour. The solvent was distilled off under reduced pressure to provide trans-4-pentylcyclohexanecarboxylic acid chloride.

Source