Reaction #640533

Reaction equation

4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

DIPEA

methoxymethyl chloride

→

title compound

4-[1-(3-Methoxy-4-methoxymethoxy-phenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

Solvents

DMF

ethyl acetate

Conditions

Workup

1. 1
   Washwashed with water
2. 2
   Dryingdried over sodium sulphate
3. 3
   FiltrationFiltration of the sodium sulphate and concentration of the filtrate under reduced pressure

Procedure

A mixture of 4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.10 g, 0.27 mmol), DIPEA and methoxymethyl chloride in dry DMF is stirred at room temperature for 14 hours. The reaction mixture is diluted with ethyl acetate, washed with water and dried over sodium sulphate. Filtration of the sodium sulphate and concentration of the filtrate under reduced pressure gives the title compound as colorless, pure solid, m.p. 190° C.

Source