Reaction #640518

Reaction equation

4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

potassium carbonate

dimethylsulfate

→

title compound

Methyl-{4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-yl}-amine

Solvents

acetone

Conditions

Workup

1. 1
   FiltrationFiltration of the solids, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel

Procedure

A suspension of 4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.10 g, 0.282 mmol, prepared according to Example 1), potassium carbonate (0.233 g, 1.69 mmol) and dimethylsulfate (0.142 g, 1.12 mmol) in acetone (5 ml) is stirred at room temperature for 16 hours. Filtration of the solids, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel using hexane-ethyl acetate as eluent gives the title compound as a colorless solid, m.p. 210-214° C.

Source