Reaction #640516

Reaction equation

Phenacylbromid

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

→

title compound

4-(1-Phenacyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

Solvents

DMF

ethyl acetate

Conditions

Workup

1. 1
   Otherat room temperature
2. 2
   Washthe organic phase is washed repeatedly with brine
3. 3
   OtherDrying of the solvent
4. 4
   Filtrationfiltering
5. 5
   Otherevaporation of the solvent under reduced pressure

Procedure

Phenacylbromid (0.1 g, 0.49 mmol) is added to an efficiently stirred suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.1 g, 0.4 mmol) [A. V. Sergievskii, O. A. Krasnoshek, S. F. Mel'nikova, I. V. Tselinskii, Russian Journal of Organic Chemistry, 2002, 38, 915-917] and potassium carbonate (0.172 g, 1.24 mmol) in dry DMF (5 ml) at room temperature. After 4 hours the reaction mixture is diluted with ethyl acetate and the organic phase is washed repeatedly with brine. Drying of the solvent, filtering and evaporation of the solvent under reduced pressure gives the title compound in crude form. The title compound is obtained in pure form by chromatography over silicagel, m.p. 202-204° C.

Source