Reaction #63871

Reaction equation

N-(3-Hydroxybenzyl)piperidine

6-bromohexanenitrile

potassium carbonate

→

6-(3-piperidinomethylphenoxy)hexanenitrile

Solvents

acetone

Conditions

Workup

1. 1
   TemperatureThe reaction mixture was cooled
2. 2
   Filtrationfiltered
3. 3
   OtherThe solvent was removed by evaporation
4. 4
   Temperaturethe residue was heated
5. 5
   Otherto remove unreacted 6-bromohexanenitrile

Procedure

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

Source