Reaction #63668

Reaction equation

tributylamine

Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate

→

2-trifluoromethyl-3,3,3-trifluoropropene

Yield 75.9%

Conditions

Workup

1. 1
   OtherIn a four necked 100 ml flask equipped with a condenser, a dropping funnel
2. 2
   Otherwas continued at the same temperature as above for 3 hours
3. 3
   workup.STIRRINGwhile stirring
4. 4
   Washwas washed with an alkaline solution
5. 5
   Otherdried with alumina
6. 6
   Temperaturecooled
7. 7
   workup.DISTILLATIONThe resultant liquid was distilled

Procedure

In a four necked 100 ml flask equipped with a condenser, a dropping funnel and a thermometer, tributylamine (20.0 g, 108 mmoles) was charged and warmed to 65° C. Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (4.88 g, 20 mmol) was dropwise added thereto while stirring. The reaction was continued at the same temperature as above for 3 hours while stirring. The gas evolved from a top of the condenser was washed with an alkaline solution, dried with alumina and cooled. The resultant liquid was distilled to give 2-trifluoromethyl-3,3,3-trifluoropropene (2.49 g). Yield, 76 %.

Source