Reaction #63588

Reaction equation

α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetic acid

thionyl chloride

→

α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetyl chloride

Solvents

trichloromethane

Conditions

Workup

1. 1
   Temperaturerefluxed for 3 hours
2. 2
   OtherThe reaction mixture was evaporated

Procedure

To a stirred solution of 29.5 parts of α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetic acid in 300 parts of trichloromethane were added 28.8 parts of thionyl chloride and the whole was stirred and refluxed for 3 hours. The reaction mixture was evaporated, yielding 30 parts of α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetyl chloride as a residue (intermediate 17).

Source