Reaction #63472

Reaction equation

2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene

sodium carbonate

→

2-(3-pyridylmethyl)-6-acetylnaphthalene

Yield 101.3%

Solvents

hydrochloric acid

Conditions

Workup

1. 1
   Extractionextracted with methylene chloride
2. 2
   DryingThe organic layer was dried over sodium sulfate
3. 3
   Otherthe solvent removed under reduced pressure

Procedure

A solution of 150 mg of 2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene in 15 ml of 1N hydrochloric acid was allowed to stand for 3 hours at room temperature. The solution was neutralized with sodium carbonate and extracted with methylene chloride. The organic layer was dried over sodium sulfate and the solvent removed under reduced pressure to give 130 mg of 2-(3-pyridylmethyl)-6-acetylnaphthalene as an oil.

Source