Reaction #633554

ord-59afda6c5bd74164bd82b40346044eac

Reaction equation

CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C=O
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbaldehyde
[Br][Mg][CH2]CCc1ccccc1
(3-phenylpropyl)magnesium bromide
→
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)CCCc1ccccc1
title compound
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)CCCc1ccccc1
1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-4-phenylbutan-1-one

Reactants

CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C=O
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbaldehyde
[Br][Mg][CH2]CCc1ccccc1
(3-phenylpropyl)magnesium bromide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared following the general procedure of Example 1 starting from (1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbaldehyde and (3-phenylpropyl)magnesium bromide.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07935848B2uspto-grants-2011_05