Reaction #632031

ord-09f9c7d244234fd989876f37982eb884

Reaction equation

CC(C)C(=O)O
isobutyric acid
C[N+](C)(C)C.[OH-]
tetramethylammonium hydroxide
→
CC(C)C(=O)[O-].C[N+](C)(C)C
title compound ( 13 )
CC(C)C(=O)[O-].C[N+](C)(C)C
Tetramethylammonium Isobutyrate

Reactants

CC(C)C(=O)O
isobutyric acid
C[N+](C)(C)C.[OH-]
tetramethylammonium hydroxide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe water was removed under reduced pressure
  2. 2
    Otherazeotroped with toluene (2×2 L)

Procedure

To a 20 L round bottom flask was added isobutyric acid (1300 mL, 14 mol), and an aqueous solution of 25% tetramethylammonium hydroxide (5 L, 14 mol). The water was removed under reduced pressure, and azeotroped with toluene (2×2 L) to leave the title compound (13) as an amber liquid, which was used without further purification.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07935686B2uspto-grants-2011_05