Reaction #632015

ord-9c40983943a74fc7b373430c458d5e26

Reaction equation

CC(C)(C)NC(=O)O.COCC1(S(N)(=O)=O)CC1
1-methoxymethylcyclopropylsulfonylamine tert-butylcarbamate
Cc1noc(C)c1N=C=O
3,5-dimethylisoxazole-4-isocyanate
→
CC(C)(C)NC(=O)O.Cc1noc(C)c1NC(=O)C1(S(N)(=O)=O)CC1
1-(3,5-dimethylisoxazol-4-yl)carbamoylcyclopropanesulfonamide tert-butylcarbamate
Yield 100.0%

Reactants

CC(C)(C)NC(=O)O.COCC1(S(N)(=O)=O)CC1
1-methoxymethylcyclopropylsulfonylamine tert-butylcarbamate
Cc1noc(C)c1N=C=O
3,5-dimethylisoxazole-4-isocyanate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThis compound was obtained in a crude 100% yield
  2. 2
    OtherThe compound was taken directly into the next reaction without purification

Procedure

This compound was obtained in a crude 100% yield according to the procedure described for the synthesis of 1-methoxymethylcyclopropylsulfonylamine tert-butylcarbamate except that 1.20 equivalents of 3,5-dimethylisoxazole-4-isocyanate was used as the electrophile. The compound was taken directly into the next reaction without purification.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07935670B2uspto-grants-2011_05