Reaction #63146

Reaction equation

2-(1,2,4-triazol-1-ylmethylamino)-4,6-dimethylpyrimidine

2-chlorophenylsulfonylisocyanate

→

urea

Yield 62.4%

N-(2-chlorophenylsulfonyl)-N'-(1,2,4-triazol-1-ylmethyl)-N'-(4,6-dimethylpyrimidin-2-yl)urea

Yield 62.4%

Solvents

acetonitrile

Conditions

Workup

1. 1
   Concentrationthe resultant solution is finally concentrated in a rotary evaporator
2. 2
   OtherCrystals of the title compound precipitate and are recrystallised from ethyl acetate

Procedure

4 g (0.019 mole) of 2-(1,2,4-triazol-1-ylmethylamino)-4,6-dimethylpyrimidine are suspended in 100 ml of absolute acetonitrile and then 4.3 g (0.019 mole) of 2-chlorophenylsulfonylisocyanate are stirred into the suspension. The batch is stirred for 24 hours at room temperature and the resultant solution is finally concentrated in a rotary evaporator. Crystals of the title compound precipitate and are recrystallised from ethyl acetate, affording 5 g (62% of theory) of the above urea, which melts at 152°-157° C.

Source