Reaction #63142

Reaction equation

2-amino-4,6-dimethylpyrimidine

methanesulfonic acid

toluene-3-sulfonic acid

sodium

formaldehyde

→

4,6-dimethyl-2-(4-tolylsulfonylmethylamino)pyrimidine

Solvents

water

Conditions

Workup

1. 1
   Otherto form a solution
2. 2
   FiltrationThe colourless precipitate is filtered with suction
3. 3
   Temperatureafter cooling
4. 4
   Otherdried

Procedure

12.7 g (0.1 mole) of 2-amino-4,6-dimethylpyrimidine are suspended in 200 ml of water and then 9.7 g (0.1 mole) of methanesulfonic acid are stirred in to form a solution. To the stirred solution are added, in succession, 18.22 g (0.1 mole) of toluene-3-sulfonic acid, sodium salt, and 9.4 g (0.11 mole) of aqueous 35% formaldehyde. The mixture is stirred for 2 hours at room temperature and for another 30 minutes at 90° C. The colourless precipitate is filtered with suction after cooling and dried. Melting point: 191°-194° C. Yield: 25 g (86% of theory).

Source