Reaction #630494

Reaction equation

methyl 5-(2',4'-dihydroxyphenyl)-5-methyl-hexanoate

2-ethyl-hexanol

p-toluene sulphonic acid

→

2-ethylhexyl 5-(2',4'-dihydroxyphenyl)-5-methyl-hexanoate

Solvents

ether

Conditions

Workup

1. 1
   Washwashed with sodium bicarbonate solution, water
2. 2
   Otherevaporated
3. 3
   Otheron a rotary evaporator at 100° C.

Procedure

5.0 Parts of methyl 5-(2',4'-dihydroxyphenyl)-5-methyl-hexanoate, 50 parts of 2-ethyl-hexanol and 0.5 parts of p-toluene sulphonic acid were heated on a steam-bath for 18 hours. The reaction mixture was then diluted with ether, washed with sodium bicarbonate solution, water, and evaporated. The residue, after stripping off excess 2-ethylhexanol on a rotary evaporator at 100° C. and 0.1 mm pressure, gave 2-ethylhexyl 5-(2',4'-dihydroxyphenyl)-5-methyl-hexanoate as a viscous amber liquid with the following percentage composition by weight.

Source