Reaction #62799

Reaction equation

4-aminomethyl-1-benzylpyrrolidin-2-one

p-chlorophenylisocyanate

→

title compound

Yield 74.9%

4-(p-Chlorophenylamino-carbonylaminomethyl)-1-benzylpyrrolidin-2-one

Yield 74.9%

Solvents

dioxane

Conditions

Workup

1. 1
   Otherthe solution is then evaporated in vacuo
2. 2
   OtherThe residue crystallizes out of ethyl acetate

Procedure

52 g (0.25 mol) of 4-aminomethyl-1-benzylpyrrolidin-2-one are stirred for 2 hours at ambient temperature in 70 ml of dioxane with 38 g (0.25 mol) of p-chlorophenylisocyanate and the solution is then evaporated in vacuo. The residue crystallizes out of ethyl acetate to yield 67 g of the title compound, m.p. 139°-140° C.

Source