Reaction #62176

ord-adcb5289bde44e6190c4869450bfc34c

Reaction equation

O=C(Cc1ccncc1)c1ccc(OCc2ccc3ccccc3n2)cc1
2-pyridin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone
CON(C)C(=O)c1ccc(OCc2ccccc2)cc1F
4-Benzyloxy-2-fluoro-N-methoxy-N-methyl-benzamide
→
O=C(Cc1ccncc1)c1ccc(OCc2ccccc2)cc1F
title compound
O=C(Cc1ccncc1)c1ccc(OCc2ccccc2)cc1F
1-(4-Benzyloxy-2-fluoro-phenyl)-2-pyridin-4-yl-ethanone

Reactants

O=C(Cc1ccncc1)c1ccc(OCc2ccc3ccccc3n2)cc1
2-pyridin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone
CON(C)C(=O)c1ccc(OCc2ccccc2)cc1F
4-Benzyloxy-2-fluoro-N-methoxy-N-methyl-benzamide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Following the procedure for the preparation of 2-pyridin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone but substituting 4-Benzyloxy-2-fluoro-N-methoxy-N-methyl-benzamide provided the title compound. MS: (M+H m/z=322.1).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07429665B2uspto-grants-2008_09