Reaction #619182

Reaction equation

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

lithium borohydride

→

desired compound

Yield 97.0%

1,1-Dicyclohexyl-3-(5-hydroxymethyl-thiazol-2-yl)-urea

Yield 97.0%

Solvents

MeOH

Conditions

Workup

1. 1
   OtherPrepared
2. 2
   OtherPurification without work-up (silica gel, 10% EtOAc and 2% MeOH in CH2Cl2)

Procedure

Prepared using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (50 mg, 0.15 mmol) and lithium borohydride (95 μL, 2M in THF) in MeOH (1 mL). Purification without work-up (silica gel, 10% EtOAc and 2% MeOH in CH2Cl2) afforded 49 mg (97%) of the desired compound.

Source