Reaction #619135

ord-9589db62766a48dba3d8e5290af1905a

Reaction equation

CC(C)(C)OC(=O)N1CCC(N(C(=O)Nc2ncc(C=O)s2)C2CCCCC2)CC1
4-[1-cyclohexyl-3-(5-formyl-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester
CN(C)S(=O)(=O)N1CCNCC1.Cl
piperazine-1-sulfonic acid dimethylamide hydrochloride
→
CN(C)S(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCC3)C3CCN(C(=O)OC(C)(C)C)CC3)s2)CC1
4-{1-Cyclohexyl-3-[5-(4-dimethylsulfamoyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester

Reactants

CC(C)(C)OC(=O)N1CCC(N(C(=O)Nc2ncc(C=O)s2)C2CCCCC2)CC1
4-[1-cyclohexyl-3-(5-formyl-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester
CN(C)S(=O)(=O)N1CCNCC1.Cl
piperazine-1-sulfonic acid dimethylamide hydrochloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherPrepared in 55% (338 mg)
  2. 2
    Otheryield

Procedure

Prepared in 55% (338 mg) yield as described in general procedure (B) from 4-[1-cyclohexyl-3-(5-formyl-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester (436 mg, 1.0 mmol) and piperazine-1-sulfonic acid dimethylamide hydrochloride (230 mg, 1.0 mmol).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE045183E1uspto-grants-2014_10