Reaction #619098

ord-ecd9222089874e178e85b84749ef1225

Reaction equation

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCOCC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-pyran-4-yl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCOCC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-pyran-4-yl)-urea
CCOC(=O)c1c[nH]c(S)n1
ethyl-2-mercapto-1H-imidazole-4-carboxylate
→
CCOC(=O)c1c[nH]c(Sc2cnc(NC(=O)N(C3CCCCC3)C3CCOCC3)s2)n1
2-{2-[3-Cyclohexyl-3-(tetrahydro-pyran-4-yl)-ureido]-thiazol-5-ylsulfanyl}-1H-imidazole-4-carboxylic acid ethyl ester

Reactants

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCOCC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-pyran-4-yl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCOCC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-pyran-4-yl)-urea
CCOC(=O)c1c[nH]c(S)n1
ethyl-2-mercapto-1H-imidazole-4-carboxylate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherPrepared

Procedure

Prepared as described in general procedure (E) using 3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-pyran-4-yl)-urea (Example 189) and ethyl-2-mercapto-1H-imidazole-4-carboxylate.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE045183E1uspto-grants-2014_10