Reaction #619095

ord-781f6daed16545c2a0fa00a8308a3759

Reaction equation

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCCCC1
3-(5-bromo-thiazol-2-yl)-1,1-dicyclohexyl-urea
COC(=O)c1cccnc1S
2-mercaptonicotinic acid methylester
→
COC(=O)c1cccnc1Sc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
2-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylsulfanyl]-nicotinic acid methyl ester

Reactants

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCCCC1
3-(5-bromo-thiazol-2-yl)-1,1-dicyclohexyl-urea
COC(=O)c1cccnc1S
2-mercaptonicotinic acid methylester

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherPrepared

Procedure

Prepared as described in general procedure (E) using 3-(5-bromo-thiazol-2-yl)-1,1-dicyclohexyl-urea and 2-mercaptonicotinic acid methylester.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE045183E1uspto-grants-2014_10