Reaction #619087

Reaction equation

water

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea

NCS

→

3-(5-Chloro-thiazol-2-yl)-1-cyclohexyl-1-piperidin-1-yl-urea

Solvents

DCM

DCM

Conditions

Workup

1. 1
   workup.ADDITIONwas added
2. 2
   DryingThe organic phase was dried (MgSO4)
3. 3
   Otherthe solvent was removed in vacuo
4. 4
   workup.ADDITIONMeCN (1 mL) was added whereupon the product
5. 5
   Otherprecipitated
6. 6
   FiltrationThe product was filtered off
7. 7
   Otherdried

Procedure

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea (50 mg, 0.16 mmol), prepared in an identical manner to Example 94 was dissolved in DCM (1 mL) and NCS (26 mg, 0.19 mmol)) was added. The reaction mixture was stirred for 3 days before DCM (20 mL) and water (20 mL) was added. The organic phase was dried (MgSO4) and the solvent was removed in vacuo. MeCN (1 mL) was added whereupon the product precipitated. The product was filtered off and dried. Yield: 20 mg.

Source