Reaction #61847

Reaction equation

1-(2-Amino-oxazol-4-yl)-naphthalen-2-ol

1-(2-amino-oxazol-4-yl)-naphthalen-2-ol

sodium hydride

Methyl bromoacetate

→

[1-(2-amino-oxazol-4-yl)-naphthalen-2-yloxy]-acetic acid methyl ester

Solvents

N,N-dimethylformamide

Conditions

Workup

1. 1
   Otherto give a dark orange solution

Procedure

1-(2-Amino-oxazol-4-yl)-naphthalen-2-ol (22, 190 mg) was dissolved in N,N-dimethylformamide and then sodium hydride (34 mg) was added in one portion to give a dark orange solution. Methyl bromoacetate (88 μL) was then added and the mixture was stirred at room temperature for 18 hours.

Source