Reaction #60774

Reaction equation

4-Amino-3-(4-aminophenyl)thieno[2,3-d]pyrimidine

1-(3,4-Dichloro-phenyl)-cyclopropanecarbonyl chloride

→

title compound

4-Amino-3-(4-((1-(3,4-dichlorophenyl)-cyclopropanecarbonyl)amino)phenyl)thieno[2,3-d]pyrimidine

Solvents

pyridine

Conditions

Workup

1. 1
   Otherthe reaction was purified by hplc

Procedure

To a solution of 4-Amino-3-(4-aminophenyl)thieno[2,3-d]pyrimidine (0.3 mL of a 0.324 M solution, 0.1 mmol) 1-(3,4-Dichloro-phenyl)-cyclopropanecarbonyl chloride (0.2 mL of a 1 M solution in pyridine, 0.2 mmol) was added in one portion. After the mixture was stirred at room temperature for 3 d, the reaction was purified by hplc to afford the title compound as a beige solid. MS(ES) m/e 455 [M+H].

Source