Reaction #607493

Reaction equation

4-bromo-2-fluorobenzoic acid

oxalyl chloride

DMF

→

4-bromo-2-fluorobenzoyl chloride

Yield 100.1%

Solvents

DCM

Conditions

Workup

1. 1
   ConcentrationThe mixture was concentrated under reduced pressure

Procedure

To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.

Source