Reaction #607487

Reaction equation

137g

3-(1,3-dioxoisoindolin-2-yl)propanoic acid

oxalyl chloride

DMF

→

3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride

Yield 92.5%

Solvents

DCM

Conditions

Workup

1. 1
   OtherUpon reaction completion
2. 2
   Concentrationthe mixture was concentrated

Procedure

To a solution of 137g (20.0 g, 91 mmol) in DCM (250 mL) were added oxalyl chloride (13.8 g, 109 mmol) and DMF (0.1 mL). See FIG. 2. The mixture was stirred at RT for 4 h. Upon reaction completion, the mixture was concentrated to give 3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 137h (20.0 g, 92%) as a white solid.

Source