Reaction #607473

ord-43c8e985ea2b4c038cf1f46e382fbb18

Reaction equation

CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
7d
CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
2-ethyl-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl) quinazoline-4 (3H)-one
Clc1ccccc1N1CCNCC1
1-(2-chlorophenyl)piperazine
→
CCc1nc2ccccc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1
3-(2-(4-(2-chlorophenyl)piperazine-1-yl)ethyl)-2-ethylquinazoline-4 (3H)-one

Reactants

CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
7d
CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
2-ethyl-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl) quinazoline-4 (3H)-one
Clc1ccccc1N1CCNCC1
1-(2-chlorophenyl)piperazine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThis compound was prepared in compliance with the procedure

Procedure

This compound was prepared in compliance with the procedure described in 7d, using 1-(2-chlorophenyl)piperazine instead of 1-(3-(trifluoromethyl)phenyl)piperazine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09326984B2uspto-grants-2016_05