Reaction #607471

ord-c314844079e84f80aa26110c5bac56a9

Reaction equation

CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
7d
CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
2-ethyl-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl) quinazoline-4 (3H)-one
COc1ccccc1N1CCNCC1
1-(2-methoxyphenyl)piperazine
→
CCc1nc2ccccc2c(=O)n1CCN1CCN(c2ccccc2OC)CC1
2-ethyl-3-(2-(4-(2-methoxyphenyl)piperazine-1-yl)ethyl)quinazoline-4 (3H)-one

Reactants

CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
7d
CCc1nc2ccccc2c(=O)n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
2-ethyl-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl) quinazoline-4 (3H)-one
COc1ccccc1N1CCNCC1
1-(2-methoxyphenyl)piperazine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThis compound was prepared in compliance with the procedure

Procedure

This compound was prepared in compliance with the procedure described in 7d, using 1-(2-methoxyphenyl)piperazine instead of 1-(3-(trifluoromethyl)phenyl)piperazine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09326984B2uspto-grants-2016_05