Reaction #607467

Reaction equation

2-ethyl-4H-3,1-benzoxazin-4-one

monoethanolamine

→

2-ethyl-3-(2-hydroxyethyl)quinazoline-4 (3H)-one

Conditions

Workup

1. 1
   OtherThe heating element was then removed
2. 2
   Other(end of the reaction)
3. 3
   workup.ADDITION100 mL were added to the reaction medium
4. 4
   Extractionthe mixture was extracted with three portions of 25 mL of ethyl acetate
5. 5
   OtherThe organic phase was separated
6. 6
   Dryingdried with magnesium sulfate
7. 7
   Otherspin dried

Procedure

1 g of 2-ethyl-4H-3,1-benzoxazin-4-one was added to 10 mL of monoethanolamine and the mixture was heated to 100° C. for 40 minutes. The heating element was then removed and the reaction medium was kept under agitation for about eight hours (end of the reaction). 100 mL were added to the reaction medium and the mixture was extracted with three portions of 25 mL of ethyl acetate. The organic phase was separated, and dried with magnesium sulfate and spin dried, yielding the 2-ethyl-3-(2-hydroxyethyl)quinazoline-4 (3H)-one compound as a yellowish oil, which solidified when left to rest at room temperature, which was used in the next stage, with no purification.

Source