Reaction #607464

ord-8ddf854728ef453db086ed0996dcf36e

Reaction equation

O=c1c2ccccc2ncn1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
1c
O=c1c2ccccc2ncn1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl) quinazoline-4 (3H)-one
Clc1ccccc1N1CCNCC1
1-(2-chlorophenyl)piperazine
→
O=c1c2ccccc2ncn1CCN1CCN(c2ccccc2Cl)CC1
3-(2-(4-(2-chlorophenyl)piperazine-1-yl)ethyl)quinazoline-4 (3H)-one

Reactants

O=c1c2ccccc2ncn1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
1c
O=c1c2ccccc2ncn1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl) quinazoline-4 (3H)-one
Clc1ccccc1N1CCNCC1
1-(2-chlorophenyl)piperazine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThis compound was prepared in compliance with the procedure

Procedure

This compound was prepared in compliance with the procedure described in 1c, using 1-(2-chlorophenyl)piperazine instead of 1-(3-(trifluoromethyl)phenyl)piperazine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09326984B2uspto-grants-2016_05