Reaction #607427

ord-f882a67ce4634ecabdcaa4beb6086fed

Reaction equation

NC(CCO)c1ccc(C(F)(F)F)cc1
3-amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol
FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(N=C=S)cc3)n2)cc1
3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole
FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(NC4=NC(c5ccc(C(F)(F)F)cc5)CCO4)cc3)n2)cc1
title compound
FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(NC4=NC(c5ccc(C(F)(F)F)cc5)CCO4)cc3)n2)cc1
N-(4-(1-(4-(Trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)-4-(4-(trifluoromethyl)phenyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared with 3-amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol and 3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole and isolated as an off-white solid (0.10 g, 43%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09326516B2uspto-grants-2016_05