Reaction #607413

Reaction equation

2-amino-2-(2-chlorophenyl)ethanol

3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole

→

title compound

1-(1-(2-Chlorophenyl)-2-hydroxyethyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thiourea

Conditions

Workup

1. 1
   Otherisolated as a white solid (1.44 g, quantitative)

Procedure

The title compound was prepared with 2-amino-2-(2-chlorophenyl)ethanol (Brueggemeier, U.; et al., WO 2010105770) and 3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole and isolated as a white solid (1.44 g, quantitative): 1H NMR (300 MHz, CDCl3) δ 7.97 (d, J=1.1 Hz, 1H), 7.64 (d, J=8.2 Hz, 1H), 7.47-7.41 (m, 1H), 7.23-7.13 (m, 2H), 6.87-6.55 (m, 11H), 5.39 (d, J=8.3 Hz, 1H), 3.48-3.30 (m, 2H).

Source