Reaction #60526

Reaction equation

[4-(4-t-butylcyclohexyl)-3-(4-butylpiperazin-1-yl)phenyl]methanol

→

crude product

Yield 85.1%

4-(4-t-Butylcyclohexyl)-3-(4-butylpiperazin-1-yl)benzaldehyde

Yield 85.1%

Solvents

chloroform

Conditions

Workup

1. 1
   Temperaturewas refluxed for 40 minutes
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Filtrationinsoluble materials were filtered off
4. 4
   ConcentrationThe filtrate was concentrated under reduced pressure

Procedure

A mixture of the crude product of [4-(4-t-butylcyclohexyl)-3-(4-butylpiperazin-1-yl)phenyl]methanol produced in Example (101a) (294 mg), manganese (IV) oxide (1.3 g, 14.95 mmol) and chloroform (15 mL) was refluxed for 40 minutes. The reaction mixture was filtered and insoluble materials were filtered off. The filtrate was concentrated under reduced pressure to give 249 mg of a crude product of the title compound as an ochre oil. This product was directly used without purification for the following reaction.

Source