Reaction #59699

Reaction equation

Ammonium chloride

t-Butyloxycarbonylhydrazine

4-bromobenzoyl chloride

DIPEA

DCM

→

4-bromo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide

Conditions

Workup

1. 1
   Otherthe organic phase was separated
2. 2
   Otherdried
3. 3
   Otherthe solvent evaporated under vacuum

Procedure

t-Butyloxycarbonylhydrazine (1.26 g) was added portionwise to a solution of 4-bromobenzoyl chloride (2.0 g), and DIPEA (2.37 ml) in DCM (20 ml) and the reaction stirred at room temperature for 18 hours. Ammonium chloride solution was added, the organic phase was separated, dried and the solvent evaporated under vacuum to give 4-bromo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide.

Source