Reaction #595930

Reaction equation

3,5-dimethoxy benzonitrile

hydroxylamine HCl

potassium carbonate

→

desired product

Yield 33.3%

N′-Hydroxy-3,5-dimethoxybenzimidamide

Yield 33.3%

Solvents

ethanol

Conditions

Workup

1. 1
   OtherThe title compound was prepared

Procedure

The title compound was prepared according to the procedure described in Intermediate-19 by using 3,5-dimethoxy benzonitrile (1.00 g, 6.13 mmol), hydroxylamine HCl (0.634 g, 9.23 mmol) and potassium carbonate (2.53 g, 18.40 mmol), ethanol (20 mL) to afford 0.400 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 3.75 (s, 6H), 5.79 (s, 2H), 6.49 (s, 1H), 6.84 (s, 2H), 9.62 (br s, 1H); MS (m/z): 197.11 (M+H)+.

Source