Reaction #595376

Reaction equation

3-bromo-1H-indazole

triethylamine

2-cyanobenzene-1-sulfonyl chloride

→

3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole

Yield 97.4%

Solvents

CH2Cl2

Conditions

Workup

1. 1
   ConcentrationAfter completion the reaction mixture was concentrated under reduced pressure
2. 2
   Otherthe product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent

Procedure

To a solution of 3-bromo-1H-indazole (200 mg, 1.02 mmol) in 2 ml CH2Cl2 was added triethylamine (308 mg, 3.05 mmol) and 2-cyanobenzene-1-sulfonyl chloride (205 mg, 1.02 mmol). The reaction mixture was stirred overnight at room temperature. After completion the reaction mixture was concentrated under reduced pressure and the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent to give 3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole (360 mg) as a yellow solid.

Source